ETHYLENE GLYCOL MONOMETHYL ETHER
MSDS Number: E5300 --- Effective Date: 03/01/00
1. Product Identification
Synonyms: 2-methoxyethanol; methyl cellosolve(R);
methoxyhydroxyethane
CAS No.: 109-86-4
Molecular Weight:
76.09
Chemical Formula: CH3OC2H4OH
Product Codes:
J.T. Baker: L718
Mallinckrodt: 4987, 5003
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------- ---------
2-Methoxyethanol 109-86-4 100% Yes
3. Hazards Identification
Emergency Overview
--------------------------
WARNING! FLAMMABLE LIQUID AND VAPOR. MAY FORM EXPLOSIVE PEROXIDES IN
AIR. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. AFFECTS CENTRAL
NERVOUS SYSTEM, BLOOD AND BLOOD FORMING ORGANS, REPRODUCTIVE SYSTEM AND
KIDNEYS. POSSIBLE BIRTH DEFECT HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL
DATA. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT.
J.T. Baker SAF-T-DATA(tm) Ratings (Provided here for
your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 3 - Severe (Life)
Flammability Rating: 2 - Moderate
Reactivity Rating: 2 - Moderate
Contact Rating: 3 - Severe (Life)
Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT
HOOD; PROPER GLOVES; CLASS B EXTINGUISHER
Storage Color Code: Red
(Flammable)
-----------------------------------------------------------------------------------------------------------
Potential Health Effects
----------------------------------
Inhalation:
Inhalation of vapors may cause irritation,
headache, dizziness, fatigue, nausea, vomiting, and loss of appetite.
Weakness, incoordination and tremors may occur.
Ingestion:
Moderately toxic. Can cause headache, fatigue, nausea, vomiting,
dizziness, and weakness. Hemorrhagic gastritis, liver damage, pancreas damage
and brain edema resulting in death has occurred in human exposure of 3 g/kg.
Damage to kidneys is possible from ingestion of large quantities.
Skin
Contact:
May cause irritation with redness and pain. May be absorbed
through the skin with possible systemic effects.
Eye Contact:
May cause irritation, redness and pain.
Chronic Exposure:
Prolonged exposure may cause injury to bone marrow, blood cells, kidney,
liver and testes. A suspected human reproductive hazard and a birth defect
hazard. Severe neurological disabilities has been reported from chronic
industrial exposure. Symptoms have included headache, dizziness, lethargy,
weakness, personality changes, apathy, unequal pupil size, and disorientation.
Aggravation of Pre-existing Conditions:
Persons with
pre-existing blood or central nervous system disorders may be more susceptible
to the effects of this substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Call a
physician.
Ingestion:
Induce vomiting immediately as directed
by medical personnel. Never give anything by mouth to an unconscious person.
Call a physician.
Skin Contact:
Immediately flush skin with
plenty of soap and water for at least 15 minutes while removing contaminated
clothing and shoes. Get medical attention. Wash clothing before reuse.
Thoroughly clean shoes before reuse.
Eye Contact:
Immediately
flush eyes with plenty of water for at least 15 minutes, lifting lower and
upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire:
Flash point: 39C (102F)
Autoignition
temperature: 286C (547F)
Flammable limits in air % by volume:
lel: 1.8;
uel: 14
Flammable.
Explosion:
Above flash point, vapor-air
mixtures are explosive within flammable limits noted above. Contact with
strong oxidizers may cause fire. Vapors can flow along surfaces to distant
ignition source and flash back. Sensitive to static discharge.
Fire
Extinguishing Media:
Dry chemical, foam or carbon dioxide. Water spray
may be used to keep fire exposed containers cool, dilute spills to
nonflammable mixtures, protect personnel attempting to stop leak and disperse
vapors.
Special Information:
In the event of a fire, wear full
protective clothing and NIOSH-approved self-contained breathing apparatus with
full facepiece operated in the pressure demand or other positive pressure
mode.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition.
Wear appropriate personal protective equipment as specified in Section 8.
Isolate hazard area. Keep unnecessary and unprotected personnel from entering.
Contain and recover liquid when possible. Use non-sparking tools and
equipment. Collect liquid in an appropriate container or absorb with an inert
material (e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush to
sewer! If a leak or spill has not ignited, use water spray to disperse the
vapors, to protect personnel attempting to stop leak, and to flush spills away
from exposures.
J. T. Baker SOLUSORB(R) solvent adsorbent is
recommended for spills of this product.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry
well-ventilated location, away from any area where the fire hazard may be
acute. Outside or detached storage is preferred. Separate from incompatibles.
Containers should be bonded and grounded for transfers to avoid static sparks.
Storage and use areas should be No Smoking areas. Use non-sparking type tools
and equipment, including explosion proof ventilation. Be aware of possible
peroxide formation. Avoid use of aluminum and magnesium equipment. Containers
of this material may be hazardous when empty since they retain product
residues (vapors, liquid); observe all warnings and precautions listed for the
product. Sudden release of hot organic chemical vapors or mists from process
equipment operating at elevated temperatures and pressure, or sudden ingress
of air into vacuum equipment, may result in ignitions without the presence of
ignition sources. Published "autoignition" or "ignition" temperature values
cannot be treated as safe operating temperatures in chemical processes without
analysis of the actual process conditions.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
2-Methoxyethanol
(EGME):
-OSHA Permissible Exposure Limit (PEL):
25 ppm (TWA) skin,
Methyl Cellosolve
-ACGIH Threshold Limit Value (TLV):
5 ppm (TWA) skin
Ventilation System:
A system of local and/or general exhaust is
recommended to keep employee exposures below the Airborne Exposure Limits.
Local exhaust ventilation is generally preferred because it can control the
emissions of the contaminant at its source, preventing dispersion of it into
the general work area. Please refer to the ACGIH document, Industrial
Ventilation, A Manual of Recommended Practices, most recent edition, for
details.
Personal Respirators (NIOSH Approved):
If the exposure
limit is exceeded, a half-face organic vapor respirator may be worn for up to
ten times the exposure limit or the maximum use concentration specified by the
appropriate regulatory agency or respirator supplier, whichever is lowest. A
full-face piece organic vapor respirator may be worn up to 50 times the
exposure limit or the maximum use concentration specified by the appropriate
regulatory agency or respirator supplier, whichever is lowest. For emergencies
or instances where the exposure levels are not known, use a full-face piece
positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators
do not protect workers in oxygen-deficient atmospheres.
Skin
Protection:
Rubber or neoprene gloves and additional protection
including impervious boots, apron, or coveralls, as needed in areas of unusual
exposure.
Eye Protection:
Use chemical safety goggles. Maintain
eye wash fountain and quick-drench facilities in work area.
9. Physical and Chemical Properties
Appearance:
Clear, colorless liquid.
Odor:
Pleasant odor.
Solubility:
Miscible in water.
Specific Gravity:
0.96 @ 20C/4C
pH:
No
information found.
% Volatiles by volume @ 21C (70F):
100
Boiling Point:
124C (255F)
Melting Point:
-85.1C
(-121F)
Vapor Density (Air=1):
2.62
Vapor Pressure (mm
Hg):
6.2 @ 20C (68F)
Evaporation Rate (BuAc=1):
ca. 1
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and
storage. Formation of explosive peroxides has been reported from
auto-oxidation. Reported to dissolve aluminum from scratched or heated
aluminum surfaces. Do not distill to dryness. Avoid excessive temperatures or
prolonged reflux, such as in batch distillations.
Hazardous
Decomposition Products:
Carbon dioxide and carbon monoxide may form
when heated to decomposition.
Hazardous Polymerization:
Will
not occur.
Incompatibilities:
Strong oxidizers and alkalis,
strong acids, high temperatures in the presence of strong bases. Contact with
excessive heat, open flame, sparks, or ignition sources.
Conditions to
Avoid:
Heat, flame, ignition sources, air, incompatibles
11. Toxicological Information
Toxicological Data:
Oral rat LD50: 2370 mg/kg;
inhalation rat LC50: 1500 ppm/7H; skin rabbit LD50: 1280 mg/kg.
Reproductive Toxicity:
In laboratory animals, this compound has
caused both birth defects and damage to the reproductive system.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
2-Methoxyethanol (109-86-4) No No None
12. Ecological Information
Environmental Fate:
When released into the soil, this
material may leach into groundwater. When released into the soil, this
material may evaporate to a moderate extent. When released into water, this
material may biodegrade to a moderate extent. This material has a log
octanol-water partition coefficient of less than 3.0. This material is not
expected to significantly bioaccumulate. When released into the air, this
material is expected to be readily degraded by reaction with photochemically
produced hydroxyl radicals. When released into the air, this material is
expected to have a half-life of less than 1 day. When released into the air,
this material may be removed from the atmosphere to a moderate extent by wet
deposition.
Environmental Toxicity:
The LC50/96-hour values for
fish are over 100 mg/l. This material is not expected to be toxic to aquatic
life.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be
handled as hazardous waste and sent to a RCRA approved incinerator or disposed
in a RCRA approved waste facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container
and unused contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: ETHYLENE GLYCOL MONOMETHYL ETHER
Hazard Class: 3
UN/NA: UN1188
Packing Group: III
Information reported for product/size: 20L
International
(Water, I.M.O.)
-----------------------------
Proper Shipping
Name: ETHYLENE GLYCOL MONOMETHYL ETHER
Hazard Class: 3.3
UN/NA: UN1188
Packing Group: III
Information reported
for product/size: 20L
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
2-Methoxyethanol (109-86-4) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
2-Methoxyethanol (109-86-4) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
2-Methoxyethanol (109-86-4) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
2-Methoxyethanol (109-86-4) No No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: Yes (Pure / Liquid)
WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO
THE STATE OF CALIFORNIA TO CAUSE BIRTH DEFECTS OR OTHER REPRODUCTIVE HARM.
Australian Hazchem Code: 2[S]
Poison Schedule: No
information found.
WHMIS:
This MSDS has been prepared according
to the hazard criteria of the Controlled Products Regulations (CPR) and the
MSDS contains all of the information required by the CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 2
Reactivity: 2
Label Hazard Warning:
WARNING! FLAMMABLE
LIQUID AND VAPOR. MAY FORM EXPLOSIVE PEROXIDES IN AIR. HARMFUL IF SWALLOWED,
INHALED OR ABSORBED THROUGH SKIN. AFFECTS CENTRAL NERVOUS SYSTEM, BLOOD AND
BLOOD FORMING ORGANS, REPRODUCTIVE SYSTEM AND KIDNEYS. POSSIBLE BIRTH DEFECT
HAZARD. MAY CAUSE BIRTH DEFECTS BASED ON ANIMAL DATA. MAY CAUSE IRRITATION TO
SKIN, EYES, AND RESPIRATORY TRACT.
Label Precautions:
Avoid
breathing vapor or mist.
Avoid contact with eyes, skin and
clothing.
Keep away from heat, sparks and flame.
Keep container
closed.
Wash thoroughly after handling.
Use only with adequate
ventilation.
Label First Aid:
If swallowed, induce vomiting
immediately as directed by medical personnel. Never give anything by mouth to
an unconscious person. If inhaled, remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. In case of
contact, immediately flush eyes or skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing before
reuse. In all cases call a physician.
Product Use:
Laboratory
Reagent.
Revision Information:
No changes.
Disclaimer:
************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the appropriate
precautionary handling of the material by a properly trained person using this
product. Individuals receiving the information must exercise their independent
judgment in determining its appropriateness for a particular purpose.
MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Strategic Services Division
Phone Number: (314)
539-1600 (U.S.A.)