XYLENES
MSDS Number: X2000 --- Effective Date: 01/14/02
1. Product Identification
Synonyms: Dimethyl benzene, xylol, methyltoluene
CAS
No.: 1330-20-7
Molecular Weight: 106.17
Chemical
Formula: C6H4(CH3)2
Product Codes: J.T. Baker: 5377, 5810,
5813, 9483, 9489, 9490, 9493, 9494, 9499, 9516, X516
Mallinckrodt: 8664,
8668, 8671, 8672, 8685, 8802, V052
2. Composition/Information on Ingredients
Ingredient CAS No Percent Hazardous
--------------------------------------- ------------ ------------ ---------
m-Xylene 108-38-3 40 - 65% No
o-Xylene 95-47-6 15 - 20% No
p-Xylene 106-42-3 < 20% No
Ethyl Benzene 100-41-4 15 - 25% Yes
3. Hazards Identification
Emergency Overview
--------------------------
DANGER! HARMFUL OR FATAL IF SWALLOWED. VAPOR HARMFUL. AFFECTS CENTRAL
NERVOUS SYSTEM. CAUSES SEVERE EYE IRRITATION. CAUSES IRRITATION TO SKIN AND
RESPIRATORY TRACT. MAY BE HARMFUL IF ABSORBED THROUGH SKIN. CHRONIC EXPOSURE
CAN CAUSE ADVERSE LIVER, KIDNEY, AND BLOOD EFFECTS. FLAMMABLE LIQUID AND
VAPOR.
SAF-T-DATA(tm) Ratings (Provided here for
your convenience)
-----------------------------------------------------------------------------------------------------------
Health Rating: 2 - Moderate (Life)
Flammability Rating: 2 - Moderate
Reactivity Rating: 1 - Slight
Contact Rating: 3 - Severe
Lab
Protective Equip: GOGGLES; LAB COAT; VENT HOOD; PROPER GLOVES; CLASS B
EXTINGUISHER
Storage Color Code: Red (Flammable)
-----------------------------------------------------------------------------------------------------------
Potential Health Effects
----------------------------------
Inhalation:
Inhalation of vapors may be irritating to the
nose and throat. Inhalation of high concentrations may result in nausea,
vomiting, headache, ringing in the ears, and severe breathing difficulties
which may be delayed in onset. Substernal pain, cough, and hoarseness are also
reported. High vapor concentrations are anesthetic and central nervous system
depressants.
Ingestion:
Ingestion causes burning sensation in
mouth and stomach, nausea, vomiting and salivation. Minute amounts aspirated
into the lungs can produce a severe hemorrhagic pneumonitis with severe
pulmonary injury or death.
Skin Contact:
Skin contact results
in loss of natural oils and often results in a characteristic dermatitis. May
be absorbed through the skin.
Eye Contact:
Vapors cause eye
irritation. Splashes cause severe irritation, possible corneal burns and eye
damage.
Chronic Exposure:
Chronic inhalation can cause
headache, loss of appetite, nervousness and pale skin. Repeated or prolonged
skin contact may cause a skin rash. Repeated exposure of the eyes to high
concentrations of vapor may cause reversible eye damage. Repeated exposure can
damage bone marrow, causing low blood cell count. May damage the liver and
kidneys.
Aggravation of Pre-existing Conditions:
Persons with
pre-existing skin disorders or eye problems, or impaired liver, kidney, blood,
or respiratory function may be more susceptible to the effects of the
substance.
4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen. Call a
physician immediately.
Ingestion:
Aspiration hazard. If
swallowed, vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting
occurs, keep head below hips to prevent aspiration into lungs. Never give
anything by mouth to an unconscious person. Call a physician immediately.
Skin Contact:
Immediately flush skin with plenty of soap and
water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical attention. Wash clothing before reuse. Thoroughly clean shoes
before reuse.
Eye Contact:
Immediately flush eyes with plenty
of water for at least 15 minutes, lifting lower and upper eyelids
occasionally. Get medical attention immediately.
5. Fire Fighting Measures
Fire:
Flash point: 29C (84F) CC
Autoignition
temperature: 464C (867F)
Flammable limits in air % by volume:
lel: 1.0;
uel: 7.0
Explosion:
Above flash point, vapor-air mixtures are
explosive within flammable limits noted above. Contact with strong oxidizers
may cause fire. Sealed containers may rupture when heated. Sensitive to static
discharge.
Fire Extinguishing Media:
Dry chemical, foam or
carbon dioxide. Water spray may be used to keep fire exposed containers cool,
dilute spills to nonflammable mixtures, protect personnel attempting to stop
leak and disperse vapors.
Special Information:
In the event of
a fire, wear full protective clothing and NIOSH-approved self-contained
breathing apparatus with full facepiece operated in the pressure demand or
other positive pressure mode. Vapors can flow along surfaces to distant
ignition source and flash back.
6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition.
Wear appropriate personal protective equipment as specified in Section 8.
Isolate hazard area. Keep unnecessary and unprotected personnel from entering.
Contain and recover liquid when possible. Use non-sparking tools and
equipment. Collect liquid in an appropriate container or absorb with an inert
material (e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush to
sewer! If a leak or spill has not ignited, use water spray to disperse the
vapors, to protect personnel attempting to stop leak, and to flush spills away
from exposures. US Regulations (CERCLA) require reporting spills and releases
to soil, water and air in excess of reportable quantities. The toll free
number for the US Coast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of
this product.
7. Handling and Storage
Protect against physical damage. Store in a cool, dry
well-ventilated location, away from any area where the fire hazard may be
acute. Outside or detached storage is preferred. Separate from incompatibles.
Containers should be bonded and grounded for transfers to avoid static sparks.
Storage and use areas should be No Smoking areas. Use non-sparking type tools
and equipment, including explosion proof ventilation. Containers of this
material may be hazardous when empty since they retain product residues
(vapors, liquid); observe all warnings and precautions listed for the product.
Do Not attempt to clean empty containers since residue is difficult to remove.
Do not pressurize, cut, weld, braze, solder, drill, grind or expose such
containers to heat, sparks, flame, static electricity or other sources of
ignition: they may explode and cause injury or death.
8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
-OSHA Permissible Exposure
Limit (PEL):
100 ppm (TWA) xylene
100 ppm (TWA) ethylbenzene
-ACGIH
Threshold Limit Value (TLV):
100 ppm (TWA) 150 ppm (STEL)
xylene
Carcinogen Category (xylene): A4
100 ppm (TWA) 125 ppm (STEL)
ethyl benzene
Ventilation System:
A system of local and/or
general exhaust is recommended to keep employee exposures below the Airborne
Exposure Limits. Local exhaust ventilation is generally preferred because it
can control the emissions of the contaminant at its source, preventing
dispersion of it into the general work area. Please refer to the ACGIH
document, Industrial Ventilation, A Manual of Recommended Practices,
most recent edition, for details. Use explosion-proof equipment.
Personal Respirators (NIOSH Approved):
If the exposure limit is
exceeded and engineering controls are not feasible, a half-face organic vapor
respirator may be worn for up to ten times the exposure limit, or the maximum
use concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. A full-face piece organic vapor respirator may
be worn up to 50 times the exposure limit, or the maximum use concentration
specified by the appropriate regulatory agency or respirator supplier,
whichever is lowest. For emergencies or instances where the exposure levels
are not known, use a full-face piece positive-pressure, air-supplied
respirator. WARNING: Air-purifying respirators do not protect workers in
oxygen-deficient atmospheres. Where respirators are required, you must have a
written program covering the basic requirements in the OSHA respirator
standard. These include training, fit testing, medical approval, cleaning,
maintenance, cartridge change schedules, etc. See 29CFR1910.134 for details.
Skin Protection:
Wear impervious protective clothing, including
boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin
contact.
Eye Protection:
Use chemical safety goggles and/or a
full face shield where splashing is possible. Maintain eye wash fountain and
quick-drench facilities in work area.
9. Physical and Chemical Properties
The following physical data is for xylene.
Appearance:
Clear, colorless liquid.
Odor:
Characteristic odor.
Solubility:
Insoluble in water.
Specific Gravity:
0.86 @ 20C/4C
pH:
Not applicable.
% Volatiles by
volume @ 21C (70F):
100
Boiling Point:
137 - 140C (279
- 284F)
Melting Point:
-25C (-13F)
Vapor Density
(Air=1):
3.7
Vapor Pressure (mm Hg):
8 @ 20C (68F)
Evaporation Rate (BuAc=1):
0.7
10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and
storage.
Hazardous Decomposition Products:
Involvement in a
fire causes formation of carbon monoxide and unidentified organic components.
Hazardous Polymerization:
Will not occur.
Incompatibilities:
Strong oxidizing agents and strong acids.
Conditions to Avoid:
Heat, flames, ignition sources and
incompatibles.
11. Toxicological Information
Toxicological Data:
Xylene: oral rat LD50: 4300 mg/kg;
inhalation rat LC50: 5000 ppm/4H; skin rabbit LD50: > 1700 mg/kg;
Irritation eye rabbit: 87 mg mild (Std. Draize); irritation skin rabbit 500
mg/24 moderate (Std. Draize); investigated as a tumorigen, mutagen,
reproductive effector.
Ethyl benzene: oral rat LD50: 3500 mg/kg; skin
rabbit LD50: 17800 uL/kg; investigated as a tumorigen, mutagen, reproductive
effector.
Reproductive Toxicity:
May cause teratogenic effects.
--------\Cancer Lists\------------------------------------------------------
---NTP Carcinogen---
Ingredient Known Anticipated IARC Category
------------------------------------ ----- ----------- -------------
m-Xylene (108-38-3) No No 3
o-Xylene (95-47-6) No No 3
p-Xylene (106-42-3) No No 3
Ethyl Benzene (100-41-4) No No 2B
12. Ecological Information
Environmental Fate:
Following data for xylene: When
released into the soil, this material may evaporate to a moderate extent. When
released into the soil, this material is expected to leach into groundwater.
When released into the soil, this material may biodegrade to a moderate
extent. When released into water, this material may evaporate to a moderate
extent. When released into water, this material may biodegrade to a moderate
extent. When released into the air, this material may be moderately degraded
by reaction with photochemically produced hydroxyl radicals. When released
into the air, this material is expected to have a half-life of less than 1
day. This material is not expected to significantly bioaccumulate. (mixed
xylenes: octanol / water partition coefficient 3.1 - 3.2; bioconcentration
factor = 1.3, eels)
Environmental Toxicity:
For xylene: This
material is expected to be slightly toxic to aquatic life. The LC50/96-hour
values for fish are between 10 and 100 mg/l.
13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be
handled as hazardous waste and sent to a RCRA approved incinerator or disposed
in a RCRA approved waste facility. Processing, use or contamination of this
product may change the waste management options. State and local disposal
regulations may differ from federal disposal regulations. Dispose of container
and unused contents in accordance with federal, state and local requirements.
14. Transport Information
Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: XYLENES
Hazard Class: 3
UN/NA: UN1307
Packing Group: III
Information reported
for product/size: 398LB
International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: XYLENES
Hazard Class: 3
UN/NA: UN1307
Packing Group: III
Information reported for product/size: 398LB
15. Regulatory Information
--------\Chemical Inventory Status - Part 1\---------------------------------
Ingredient TSCA EC Japan Australia
----------------------------------------------- ---- --- ----- ---------
m-Xylene (108-38-3) Yes Yes Yes Yes
o-Xylene (95-47-6) Yes Yes Yes Yes
p-Xylene (106-42-3) Yes Yes Yes Yes
Ethyl Benzene (100-41-4) Yes Yes Yes Yes
--------\Chemical Inventory Status - Part 2\---------------------------------
--Canada--
Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- -----
m-Xylene (108-38-3) Yes Yes No Yes
o-Xylene (95-47-6) Yes Yes No Yes
p-Xylene (106-42-3) Yes Yes No Yes
Ethyl Benzene (100-41-4) Yes Yes No Yes
--------\Federal, State & International Regulations - Part 1\----------------
-SARA 302- ------SARA 313------
Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- --------------
m-Xylene (108-38-3) No No Yes No
o-Xylene (95-47-6) No No Yes No
p-Xylene (106-42-3) No No Yes No
Ethyl Benzene (100-41-4) No No Yes No
--------\Federal, State & International Regulations - Part 2\----------------
-RCRA- -TSCA-
Ingredient CERCLA 261.33 8(d)
----------------------------------------- ------ ------ ------
m-Xylene (108-38-3) 1000 No No
o-Xylene (95-47-6) 1000 No No
p-Xylene (106-42-3) 100 No Yes
Ethyl Benzene (100-41-4) 1000 No No
Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: Yes Pressure: No
Reactivity: No (Mixture / Liquid)
Australian Hazchem Code: 3[Y]
Poison
Schedule: None allocated.
WHMIS:
This MSDS has been
prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the
CPR.
16. Other Information
NFPA Ratings: Health: 2 Flammability: 3
Reactivity: 0
Label Hazard Warning:
DANGER! HARMFUL OR
FATAL IF SWALLOWED. VAPOR HARMFUL. AFFECTS CENTRAL NERVOUS SYSTEM. CAUSES
SEVERE EYE IRRITATION. CAUSES IRRITATION TO SKIN AND RESPIRATORY TRACT. MAY BE
HARMFUL IF ABSORBED THROUGH SKIN. CHRONIC EXPOSURE CAN CAUSE ADVERSE LIVER,
KIDNEY, AND BLOOD EFFECTS. FLAMMABLE LIQUID AND VAPOR.
Label
Precautions:
Keep away from heat, sparks and flame.
Avoid contact
with eyes, skin and clothing.
Keep container closed.
Use only with
adequate ventilation.
Avoid breathing vapor.
Wash thoroughly after
handling.
Label First Aid:
Aspiration hazard. If swallowed,
vomiting may occur spontaneously, but DO NOT INDUCE. If vomiting occurs, keep
head below hips to prevent aspiration into lungs. Never give anything by mouth
to an unconscious person. Call a physician immediately. If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. In case of contact, immediately flush eyes or skin
with plenty of water for at least 15 minutes while removing contaminated
clothing and shoes. Wash clothing before reuse. In all cases get medical
attention immediately.
Product Use:
Laboratory Reagent.
Revision Information:
MSDS Section(s) changed since last
revision of document include: 3.
Disclaimer:
************************************************************************************************
Mallinckrodt Baker, Inc. provides the information contained herein in
good faith but makes no representation as to its comprehensiveness or
accuracy. This document is intended only as a guide to the appropriate
precautionary handling of the material by a properly trained person using this
product. Individuals receiving the information must exercise their independent
judgment in determining its appropriateness for a particular purpose.
MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER
EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE
INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS.
ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES
RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
************************************************************************************************
Prepared by: Environmental Health & Safety
Phone Number:
(314) 654-1600 (U.S.A.)